Lithium amidoborane, a highly chemoselective reagent for the reduction of α,β-unsaturated ketones to allylic alcohols.
نویسندگان
چکیده
Lithium amidoborane (LiNH(2)BH(3), LiAB for short), is capable of chemoselectively reducing α,β-unsaturated ketones to the corresponding allylic alcohols at ambient temperature. A mechanistic study shows that the reduction is via a double hydrogen transfer process. The protic H(N) and hydridic H(B) in amidoborane add to the O and C sites of the carbonyl group, respectively.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 2 شماره
صفحات -
تاریخ انتشار 2012